Compound Detail
CHEMBL6008231
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Basic Information
| ChEMBL ID | CHEMBL6008231 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LVEHKTVORFLZRU-HAQNSBGRSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
309.4
MW (Da)
3.05
ALogP
5
HBA
2
HBD
90.5
PSA (Ų)
0.78
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 CHEMBL2148 | IC50 | 7.87 | 7.87 | 13.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 | IC50 | = | 13.4 | nM | 7.87 | Enzymatic Inhibition Assay: Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standar... | - |
| Tyrosine-protein kinase JAK3 | IC50 | = | 13.4 | nM | 7.87 | Enzymatic Inhibition Assay: 11-point dosing series were made for each compound b... | - |
Data from ChEMBL 36 via Core Engine