Compound Detail
CHEMBL6016384
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CCOC(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(S(C)(=O)=O)cc3)c12
Basic Information
| ChEMBL ID | CHEMBL6016384 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SAXBCTJESUGKOB-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
510.6
MW (Da)
3.66
ALogP
9
HBA
1
HBD
111.9
PSA (Ų)
0.38
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| EZH2/SUZ12/EED complex CHEMBL3137286 | IC50 | 9.15 | 8.55 | 0.7 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| EZH2/SUZ12/EED complex | IC50 | = | 0.7 | nM | 9.15 | ELISA (H3K27 Methylation) Assay: Representative compounds of the present inventi... | - |
| EZH2/SUZ12/EED complex | IC50 | = | 5.4 | nM | 8.27 | EED-H3K27Me3 Peptide Competition Binding Assay by AlphaScreen: To assess the com... | - |
| EZH2/SUZ12/EED complex | IC50 | = | 5.9 | nM | 8.23 | EED LC-MS Assay: Representative compounds of the present invention were serially... | - |
Data from ChEMBL 36 via Core Engine