EZH2/SUZ12/EED complex · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q15910. Use UniProt Q15910 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q15910 as the stable identity anchor, then attach disease evidence before program review.
Histone-lysine N-methyltransferase EZH2
Review this target as EZH2/SUZ12/EED complex, mapped to UniProt Q15910. ChEMBL maps the protein component as Histone-lysine N-methyltransferase EZH2. Sequence length is 746 aa.
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This review treats EZH2/SUZ12/EED complex as ChEMBL target CHEMBL3137286, mapped to UniProt Q15910. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | EZH2/SUZ12/EED complex |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | Q15910 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone-lysine N-methyltransferase EZH2 |
| UniProt Accession | Q15910 |
| Component Type | Protein |
| Sequence Length | 746 aa |
Histone-lysine N-methyltransferase EZH2
Review this target as EZH2/SUZ12/EED complex, mapped to UniProt Q15910. ChEMBL maps the protein component as Histone-lysine N-methyltransferase EZH2. Sequence length is 746 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4645324 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL6016384 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL6004759 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL5933888 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL5766995 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL6025392 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL5795236 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL5951716 | 8.8 | IC50 | 1.6 | Preclinical |
| CHEMBL4104741 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL5971900 | 8.72 | IC50 | 1.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 14 | 427 | 7.7 |
| assay format | 1 | 117 | 7.6 |