Compound Detail
CHEMBL6017428
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CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)c2ccc(C(=O)Nc3ccc4c(c3)CN(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SCCOC=O)[C@H](C(=O)NC3CCCc5ccccc53)C4)cc2)CC1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
Basic Information
| ChEMBL ID | CHEMBL6017428 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HCNKRWOIEAHXFI-FDXINOCVSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
1197.5
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Baculoviral IAP repeat-containing protein 2/Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP CHEMBL6066574 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP CHEMBL6066573 | IC50 | 7.77 | 7.77 | 17.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Baculoviral IAP repeat-containing protein 2/Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP | IC50 | = | 12.0 | nM | 7.92 | Homogeneous Time Resolved Fluorescence (HTRF) Assay: Assays were performed in bl... | - |
| Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP | IC50 | = | 17.0 | nM | 7.77 | Homogeneous Time Resolved Fluorescence (HTRF) Assay: Assays were performed in bl... | - |
Data from ChEMBL 36 via Core Engine