Compound Detail
CHEMBL6022087
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Basic Information
| ChEMBL ID | CHEMBL6022087 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XMTXIAOVOLGUTI-HNNXBMFYSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
391.3
MW (Da)
2.89
ALogP
4
HBA
2
HBD
75.6
PSA (Ų)
0.79
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 7.32
IC50 1 meas. best 7.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelial PAS domain-containing protein 1 CHEMBL1744522 | IC50 | 7.51 | 7.51 | 31.0 | 1 |
| Vascular endothelial growth factor A, long form CHEMBL1783 | EC50 | 7.32 | 7.32 | 48.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelial PAS domain-containing protein 1 | IC50 | = | 31.0 | nM | 7.51 | Scintillation Proximity Assay (SPA): HIF-2a: The total assay volume was about 10... | - |
| Vascular endothelial growth factor A, long form | EC50 | = | 48.0 | nM | 7.32 | ELISA Assay: Four hours later, serial dilutions of 10× compound stocks were made... | - |
| Vascular endothelial growth factor A, long form | EC50 | = | 48.0 | nM | 7.32 | ELISA Assay: About 7500 of 786-0 cells in 180 μL of growth medium were seeded in... | - |
| Vascular endothelial growth factor A, long form | EC50 | = | 48.0 | nM | 7.32 | ELISA Assay: VEGF: Four hours later, serial dilutions of 10x compound stocks wer... | - |
Data from ChEMBL 36 via Core Engine