Compound Detail
CHEMBL60238
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Basic Information
| ChEMBL ID | CHEMBL60238 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LYCSUAGKQMUTBR-ZWNOBZJWSA-N |
2
Targets
7
Activities
3
Assay Types
0
PK Parameters
14
Publications
0
Known Names
Molecular Properties
264.3
MW (Da)
0.13
ALogP
4
HBA
3
HBD
103.9
PSA (Ų)
0.71
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas.
Ki 3 meas. best 4.7
EC50 1 meas. best 4.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 6 CHEMBL3842 | EC50 | 4.7 | 4.7 | 20000.0 | 1 |
| Metabotropic glutamate receptor 6 CHEMBL4573 | Ki | 4.7 | 4.7 | 20000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 6 | EC50 | = | 20000.0 | nM | 4.7 | Tested for the agonistic activity against Metabotropic glutamate receptor 6 | - |
| Metabotropic glutamate receptor 6 | Ki | = | 20000.0 | nM | 4.7 | Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6). | 10893301 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9873471 | 10.1016/s0960-894x(98)00352-7 | Metabotropic glutamate receptor 1 | 2 |
| 9873471 | 10.1016/s0960-894x(98)00352-7 | Metabotropic glutamate receptor 5 | 2 |
| 9873471 | 10.1016/s0960-894x(98)00352-7 | Metabotropic glutamate receptor 2 | 2 |
| 9873471 | 10.1016/s0960-894x(98)00352-7 | Metabotropic glutamate receptor 3 | 2 |
| 9873471 | 10.1016/s0960-894x(98)00352-7 | Metabotropic glutamate receptor 4 | 2 |
| 9873471 | 10.1016/s0960-894x(98)00352-7 | Metabotropic glutamate receptor 8 | 2 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 1 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 2 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 5 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 6 | 1 |
| - | 10.1016/S0960-894X(97)00068-1 | Metabotropic glutamate receptor 1 | 1 |
| - | 10.1016/S0960-894X(97)00068-1 | Metabotropic glutamate receptor 5 | 1 |
| - | 10.1016/S0960-894X(97)00068-1 | Metabotropic glutamate receptor 2 | 1 |
| - | 10.1016/S0960-894X(97)00068-1 | Metabotropic glutamate receptor 6 | 1 |
Data from ChEMBL 36 via Core Engine