Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL718130

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Metabotropic glutamate receptor 6 (CHEMBL4573)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Ligands for glutamate receptors: design and therapeutic prospects.
Bräuner-Osborne H, Egebjerg J, Nielsen EO, Madsen U, Krogsgaard-Larsen P.
J Med Chem (2000) 43 : 2609 -2645
PubMed 10893301 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 5.18 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL275079 LY-379268 1 6.40
CHEMBL33567 1 6.05
CHEMBL88999 1 5.62
CHEMBL8759 EGLUMETAD 2.0 1 5.52
CHEMBL277475 1 5.33
CHEMBL90501 1 5.28
CHEMBL280563 1 5.24
CHEMBL60238 1 4.70
CHEMBL575060 GLUTAMIC ACID 3.0 1 4.42
CHEMBL315268 1 4.24
CHEMBL34453 1 4.22
CHEMBL88612 1 -
CHEMBL279956 QUISQUALATE 1 -
CHEMBL88553 1 -
CHEMBL297150 1 -
CHEMBL40086 1 -
CHEMBL86508 1 -
CHEMBL277961 1 -
CHEMBL66654 1 -
CHEMBL88804 (S)-2-AMINOADIPIC ACID 1 -
CHEMBL313713 1 -
CHEMBL313394 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL275079 LY-379268 Ki = 400.0 nM 6.40
CHEMBL33567 Ki = 900.0 nM 6.05
CHEMBL88999 Ki = 2400.0 nM 5.62
CHEMBL8759 EGLUMETAD Ki = 3000.0 nM 5.52
CHEMBL277475 Ki = 4700.0 nM 5.33
CHEMBL90501 Ki = 5300.0 nM 5.28
CHEMBL280563 Ki = 5800.0 nM 5.24
CHEMBL60238 Ki = 20000.0 nM 4.70
CHEMBL575060 GLUTAMIC ACID Ki = 38000.0 nM 4.42
CHEMBL315268 Ki = 58000.0 nM 4.24
CHEMBL34453 Ki = 60000.0 nM 4.22
CHEMBL88612 Ki > 100000.0 nM -
CHEMBL279956 QUISQUALATE Ki = 1000000.0 nM -
CHEMBL88553 Ki > 100000.0 nM -
CHEMBL297150 Ki > 1000000.0 nM -
CHEMBL40086 Ki = 110000.0 nM -
CHEMBL86508 Ki = 480000.0 nM -
CHEMBL277961 Ki > 1000000.0 nM -
CHEMBL66654 Ki > 10000.0 nM -
CHEMBL88804 (S)-2-AMINOADIPIC ACID Ki = 140000.0 nM -
CHEMBL313713 Ki > 1000000.0 nM -
CHEMBL313394 Ki > 1000000.0 nM -