Compound Detail
CHEMBL277961
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Basic Information
| ChEMBL ID | CHEMBL277961 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZNQZXIHSJUDIKL-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
257.2
MW (Da)
-0.33
ALogP
3
HBA
4
HBD
120.8
PSA (Ų)
0.54
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.52
Ki 1 meas. best 4.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL2851 | IC50 | 4.52 | 4.52 | 30000.0 | 1 |
| Metabotropic glutamate receptor 2 CHEMBL5137 | Ki | 4.52 | 4.52 | 30000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | IC50 | = | 30000.0 | nM | 4.52 | Antagonistic activity against Metabotropic glutamate receptor 2 was determined | - |
| Metabotropic glutamate receptor 2 | Ki | = | 30000.0 | nM | 4.52 | Antagonist potency against cloned Metabotropic glutamate receptor 2 | 10893301 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 1 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 2 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 5 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 6 | 1 |
| - | 10.1016/S0960-894X(97)00177-7 | Metabotropic glutamate receptor 1 | 1 |
| - | 10.1016/S0960-894X(97)00177-7 | Metabotropic glutamate receptor 5 | 1 |
| - | 10.1016/S0960-894X(97)00177-7 | Metabotropic glutamate receptor 2 | 1 |
| - | 10.1016/S0960-894X(97)00177-7 | Metabotropic glutamate receptor 6 | 1 |
Data from ChEMBL 36 via Core Engine