Assay Detail
Functional
CHEMBL872681
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Antagonistic activity against Metabotropic glutamate receptor 2 was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 2 (CHEMBL2851) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.62 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18439 | — | — | 1 | 4.96 |
| CHEMBL277961 | — | — | 1 | 4.52 |
| CHEMBL278949 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18439 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL277961 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL278949 | — | IC50 | = | 43000.0 | nM | 4.37 |