Compound Detail
CHEMBL297150
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Basic Information
| ChEMBL ID | CHEMBL297150 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MJUZIVFENBZUFH-AWFVSMACSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
13
Publications
0
Known Names
Molecular Properties
189.2
MW (Da)
-2.20
ALogP
5
HBA
4
HBD
129.9
PSA (Ų)
0.36
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.32
Ki 2 meas. best 5.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL2851 | EC50 | 5.32 | 5.32 | 4800.0 | 1 |
| Metabotropic glutamate receptor 2 CHEMBL5137 | Ki | 5.32 | 5.32 | 4800.0 | 1 |
| Metabotropic glutamate receptor 3 CHEMBL2888 | EC50 | 4.28 | 4.28 | 52000.0 | 1 |
| Metabotropic glutamate receptor 3 CHEMBL2888 | Ki | 4.28 | 4.28 | 52000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | EC50 | = | 4800.0 | nM | 5.32 | Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGlu... | 10397508 |
| Metabotropic glutamate receptor 2 | Ki | = | 4800.0 | nM | 5.32 | Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2). | 10893301 |
| Metabotropic glutamate receptor 3 | EC50 | = | 52000.0 | nM | 4.28 | Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing chim... | 10397508 |
| Metabotropic glutamate receptor 3 | Ki | = | 52000.0 | nM | 4.28 | Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3). | 10893301 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10397508 | 10.1016/s0960-894x(99)00266-8 | NON-PROTEIN TARGET | 4 |
| 10397508 | 10.1016/s0960-894x(99)00266-8 | Metabotropic glutamate receptor 2 | 1 |
| 10397508 | 10.1016/s0960-894x(99)00266-8 | Metabotropic glutamate receptor 3 | 1 |
| 10397508 | 10.1016/s0960-894x(99)00266-8 | Metabotropic glutamate receptor 1 | 1 |
| 10397508 | 10.1016/s0960-894x(99)00266-8 | Metabotropic glutamate receptor 5 | 1 |
| 10397508 | 10.1016/s0960-894x(99)00266-8 | Metabotropic glutamate receptor 4 | 1 |
| 10397508 | 10.1016/s0960-894x(99)00266-8 | Metabotropic glutamate receptor 6 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 1 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 2 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 3 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 4 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 5 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 6 | 1 |
Data from ChEMBL 36 via Core Engine