Assay Detail
Functional
CHEMBL820028
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Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 2 (CHEMBL2851) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.98 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40086 | — | — | 1 | 6.70 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.21 |
| CHEMBL34453 | — | — | 1 | 5.68 |
| CHEMBL297150 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40086 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL34453 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL297150 | — | EC50 | = | 4800.0 | nM | 5.32 |