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Compound Detail

CHEMBL6029336

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CC(C)(C=C(C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21)N1CCOCC1

Basic Information

ChEMBL ID CHEMBL6029336
Phase Preclinical
Structure Type MOL
InChI Key NZIQNLGMMJGSQU-QHCPKHFHSA-N
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

610.7
MW (Da)
4.56
ALogP
10
HBA
1
HBD
135.4
PSA (Ų)
0.22
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C33H35FN8O3
MW 610.69
Aromatic Rings 4
Heavy Atoms 45
NP-Likeness -1.08

Activity Summary

IC50 3 meas. best 9.15

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Tyrosine-protein kinase BTK
CHEMBL5251
IC50 9.15 8.71 0.7 3

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine