Compound Detail
CHEMBL6032205
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Basic Information
| ChEMBL ID | CHEMBL6032205 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DFMIYIGMTZUMHD-UHFFFAOYSA-N |
4
Targets
5
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
460.6
MW (Da)
5.45
ALogP
5
HBA
2
HBD
75.2
PSA (Ų)
0.29
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 8.08
EC50 1 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 4 CHEMBL1853 | Ki | 8.08 | 8.08 | 8.4 | 1 |
| Somatostatin receptor type 3 CHEMBL2028 | EC50 | 8.0 | 8.0 | 10.0 | 1 |
| Somatostatin receptor type 1 CHEMBL1917 | Ki | 5.61 | 5.61 | 2451.0 | 1 |
| Somatostatin receptor type 3 CHEMBL2028 | Ki | 5.23 | 5.23 | 5934.0 | 1 |
| Somatostatin receptor type 2 CHEMBL1804 | Ki | 5.09 | 5.09 | 8094.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 4 | Ki | = | 8.39 | nM | 8.08 | Radioligand Binding Assay: Competitive radioligand binding experiments were perf... | - |
| Somatostatin receptor type 3 | EC50 | = | 10.0 | nM | 8.0 | Activity Assays: Measurement of forskolin stimulated inhibition of cAMP was perf... | - |
| Somatostatin receptor type 1 | Ki | = | 2451.0 | nM | 5.61 | Radioligand Binding Assay: Competitive radioligand binding experiments were perf... | - |
| Somatostatin receptor type 3 | Ki | = | 5934.0 | nM | 5.23 | Radioligand Binding Assay: Competitive radioligand binding experiments were perf... | - |
| Somatostatin receptor type 2 | Ki | = | 8094.0 | nM | 5.09 | Radioligand Binding Assay: Competitive radioligand binding experiments were perf... | - |
Data from ChEMBL 36 via Core Engine