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Compound Detail

CHEMBL6037535

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Cc1cccn2c(C(C)(C)NC(=O)[C@H]3[C@@H]4CNC[C@@H]43)nc(C3CC3)c12
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL6037535
Phase Preclinical
Structure Type MOL
InChI Key AIWOECVGPNINAN-FICVDOATSA-N
3
Targets
11
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

338.5
MW (Da)
2.34
ALogP
4
HBA
2
HBD
58.4
PSA (Ų)
0.90
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H26N4O
MW 338.46
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -0.71

Activity Summary

Ki 9 meas. best 8.12
EC50 2 meas. best 9.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Somatostatin receptor type 4
CHEMBL1853
 EC50 9.4 9.4 0.4 2
Somatostatin receptor type 4
CHEMBL1853
 Ki 8.12 8.12 7.6 3
Somatostatin receptor type 1
CHEMBL1917
 Ki 5.96 5.96 1100.0 3
Somatostatin receptor type 3
CHEMBL2028
 Ki 5.21 5.21 6180.0 3

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Somatostatin receptor type 4 EC50 = 0.4 nM 9.4 AMP Assay with Human Somatostatin 4 Receptor: The activation of the SSTR4 recept... -
Somatostatin receptor type 4 EC50 = 0.4 nM 9.4 cAMP ASSAY: The activation of the SSTR4 receptor (Gi coupled) causes an inhibiti... -
Somatostatin receptor type 4 Ki = 7.6 nM 8.12 Radiogland Binding Assays: For the binding experiments 200 μL of membrane homoge... -
Somatostatin receptor type 4 Ki = 7.6 nM 8.12 Radioligand Binding Assay: Receptor binding assays refer to a technique in which... -
Somatostatin receptor type 4 Ki = 7.6 nM 8.12 Radioligand Binding Assays: Receptor binding assays refer to a technique in whic... -
Somatostatin receptor type 1 Ki = 1100.0 nM 5.96 Radiogland Binding Assays: For the binding experiments 200 μL of membrane homoge... -
Somatostatin receptor type 1 Ki = 1100.0 nM 5.96 Radioligand Binding Assay: Receptor binding assays refer to a technique in which... -
Somatostatin receptor type 1 Ki = 1100.0 nM 5.96 Radioligand Binding Assays: Receptor binding assays refer to a technique in whic... -
Somatostatin receptor type 3 Ki = 6180.0 nM 5.21 Radiogland Binding Assays: For the binding experiments 200 μL of membrane homoge... -
Somatostatin receptor type 3 Ki = 6180.0 nM 5.21 Radioligand Binding Assay: Receptor binding assays refer to a technique in which... -
Somatostatin receptor type 3 Ki = 6180.0 nM 5.21 Radioligand Binding Assays: Receptor binding assays refer to a technique in whic... -

Data from ChEMBL 36 via Core Engine