Compound Detail
CHEMBL604373
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CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL604373 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | LTAFNTKZCARRFJ-HPWFANMZSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
2828.3
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 10.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Galanin receptor type 1 CHEMBL4894 | Ki | 10.1 | 10.1 | 0.1 | 1 |
| Galanin receptor type 2 CHEMBL3176 | Ki | 9.22 | 9.22 | 0.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Galanin receptor type 1 | Ki | = | 0.08 | nM | 10.1 | Binding affinity to human GalR1 | 20121116 |
| Galanin receptor type 2 | Ki | = | 0.6 | nM | 9.22 | Binding affinity to human GalR2 | 20121116 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20121116 | 10.1021/jm9018349 | Galanin receptor type 1 | 1 |
| 20121116 | 10.1021/jm9018349 | Galanin receptor type 2 | 1 |
Data from ChEMBL 36 via Core Engine