Compound Detail
CHEMBL6054505
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Basic Information
| ChEMBL ID | CHEMBL6054505 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XQRVINZFDOUPSD-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
443.5
MW (Da)
4.46
ALogP
9
HBA
2
HBD
97.8
PSA (Ų)
0.38
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| TGF-beta receptor type-1 CHEMBL4439 | IC50 | 8.77 | 8.77 | 1.7 | 1 |
| TGF-beta receptor type-2 CHEMBL4267 | IC50 | 6.09 | 6.09 | 810.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| TGF-beta receptor type-1 | IC50 | = | 1.7 | nM | 8.77 | Biological Assays: Assays are conducted in 1536-well plates and 2 mL reactions a... | - |
| TGF-beta receptor type-2 | IC50 | = | 810.0 | nM | 6.09 | Biological Assays: Assays are conducted in 1536-well plates and 2 mL reactions a... | - |
Data from ChEMBL 36 via Core Engine