Compound Detail

CHEMBL6055730

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N#Cc1cc(F)cc(Oc2ccc(S(=N)(=O)C(F)(F)F)c3c2CC(F)(F)[C@H]3O)c1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL6055730
Phase	Preclinical
Structure Type	MOL
InChI Key	IQQMXOMGOJTTIO-AYBWSJBYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

436.3

MW (Da)

4.64

ALogP

HBA

HBD

94.2

PSA (Å²)

0.69

QED

Ro5 Violations

Rot. Bonds

Availability	Unknown
Chirality	Unknown

First in Class Prodrug

EC50 6 meas. best 7.72

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Vascular endothelial growth factor A, long form CHEMBL1783	EC50	7.72	7.715	19.2	6

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Vascular endothelial growth factor A, long form	EC50	=	19.2	nM	7.72	ELISA Assay: Four hours later, serial dilutions of 10× compound stocks were made...	-
Vascular endothelial growth factor A, long form	EC50	=	19.2	nM	7.72	ELISA Assay: About 7500 of 786-0 cells in 180 μL of growth medium were seeded in...	-
Vascular endothelial growth factor A, long form	EC50	=	19.2	nM	7.72	ELISA Assay: VEGF: Four hours later, serial dilutions of 10x compound stocks wer...	-
Vascular endothelial growth factor A, long form	EC50	=	19.5	nM	7.71	ELISA Assay: Four hours later, serial dilutions of 10× compound stocks were made...	-
Vascular endothelial growth factor A, long form	EC50	=	19.5	nM	7.71	ELISA Assay: About 7500 of 786-0 cells in 180 μL of growth medium were seeded in...	-
Vascular endothelial growth factor A, long form	EC50	=	19.5	nM	7.71	ELISA Assay: VEGF: Four hours later, serial dilutions of 10x compound stocks wer...	-

Data from ChEMBL 36 via Core Engine