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Compound Detail

CHEMBL6058232

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O=c1[nH]c2ccc(CCN3CCN(c4cccc5sccc45)CC3)cc2s1

Basic Information

ChEMBL ID CHEMBL6058232
Phase Preclinical
Structure Type MOL
InChI Key MUJGHQUEXWAKFG-UHFFFAOYSA-N
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

395.6
MW (Da)
4.17
ALogP
5
HBA
1
HBD
39.3
PSA (Ų)
0.56
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H21N3OS2
MW 395.55
Aromatic Rings 4
Heavy Atoms 27
NP-Likeness -1.68

Activity Summary

IC50 2 meas. best 8.12
EC50 1 meas. best 8.67

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 1A
CHEMBL214
EC50 8.67 8.67 2.1 1
5-hydroxytryptamine receptor 2A
CHEMBL224
IC50 8.12 8.12 7.6 1
D(2) dopamine receptor
CHEMBL217
IC50 7.31 7.31 48.8 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine