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Compound Detail

CHEMBL6068336

MOMELOTINIB DIHYDROCHLORIDE MONOHYDRATE
💊 Approved Drug
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💊 Approved Drug
Cl.Cl.N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1.O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL6068336
Name MOMELOTINIB DIHYDROCHLORIDE MONOHYDRATE
Phase Approved
Structure Type MOL
InChI Key RQKCPSIFARJBOR-UHFFFAOYSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL1078178
Active Moiety CHEMBL1078178

Known Names

CYT-11387 DIHYDROCHLORIDE MONOHYDRATE CYT-387 DIHYDROCHLORIDE MONOHYDRATE Momelotinib dihydrochloride monohydrate Momelotinib hydrochloride hydrate Omjjara
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
5
Known Names
2
Indications
4
Mechanisms

Molecular Properties

414.5
MW (Da)
2.98
ALogP
7
HBA
2
HBD
103.2
PSA (Ų)
0.60
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2024
Availability Unknown
Chirality Achiral
USAN Stem -tinib

Extended Properties

Molecular Formula C23H26Cl2N6O3
MW 505.41
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -1.88

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Tyrosine-protein kinase JAK2 inhibitor INHIBITOR Tyrosine-protein kinase JAK2 ✓ ✓
Tyrosine-protein kinase JAK1 inhibitor INHIBITOR Tyrosine-protein kinase JAK1 ✓ ✓
Tyrosine-protein kinase JAK2 inhibitor INHIBITOR Tyrosine-protein kinase JAK2 ✓ ✓
Activin receptor type-1 inhibitor INHIBITOR Activin receptor type-1 ✓ ✓

Indications

Myeloproliferative Disorders Splenomegaly

Data from ChEMBL 36 via Core Engine