Compound Detail
CHEMBL609702
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Basic Information
| ChEMBL ID | CHEMBL609702 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TYWHSGIYNMFJBG-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
180.2
MW (Da)
0.90
ALogP
3
HBA
3
HBD
105.0
PSA (Ų)
0.27
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 4.69
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Urokinase-type plasminogen activator CHEMBL3286 | Ki | 4.69 | 4.69 | 20600.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Urokinase-type plasminogen activator | Ki | = | 20600.0 | nM | 4.69 | Inhibition against Urokinase-type plasminogen activator | 2231595 |
| Urokinase-type plasminogen activator | Ki | = | 20606.3 | nM | 4.69 | log1/Ki value was calculated against Urokinase-type plasminogen activator | 2231595 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2231595 | 10.1021/jm00173a008 | Urokinase-type plasminogen activator | 2 |
| 2231595 | 10.1021/jm00173a008 | Serine protease 1 | 2 |
| 2231595 | 10.1021/jm00173a008 | Plasminogen | 1 |
| 2231595 | 10.1021/jm00173a008 | Prothrombin | 1 |
| 2231595 | 10.1021/jm00173a008 | Tissue-type plasminogen activator | 1 |
| 2231595 | 10.1021/jm00173a008 | Plasma kallikrein | 1 |
Data from ChEMBL 36 via Core Engine