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Assay Detail

CHEMBL816645

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Binding
Inhibition against Urokinase-type plasminogen activator
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Urokinase-type plasminogen activator (CHEMBL3286)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses.
Yang H, Henkin J, Kim KH, Greer J.
J Med Chem (1990) 33 : 2956 -2961
PubMed 2231595 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 4.58 5.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL41040 1 5.22
CHEMBL43961 1 5.19
CHEMBL43415 1 4.81
CHEMBL14047 PHENYLGUANIDINE 1 4.69
CHEMBL609702 1 4.69
CHEMBL1160763 1 4.51
CHEMBL609703 1 4.26
CHEMBL13823 1 4.21
CHEMBL1160766 1 4.14
CHEMBL404605 1 4.04
CHEMBL1160769 1 -
CHEMBL1160768 1 -
CHEMBL20767 4-GUANIDINO-BENZOIC ACID 1 -
CHEMBL297076 1 -
CHEMBL41853 1 -
CHEMBL1160764 1 -
CHEMBL1160765 1 -
CHEMBL44236 1 -
CHEMBL1160767 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL41040 Ki = 6070.0 nM 5.22
CHEMBL43961 Ki = 6490.0 nM 5.19
CHEMBL43415 Ki = 15600.0 nM 4.81
CHEMBL14047 PHENYLGUANIDINE Ki = 20600.0 nM 4.69
CHEMBL609702 Ki = 20600.0 nM 4.69
CHEMBL1160763 Ki = 30700.0 nM 4.51
CHEMBL609703 Ki = 54300.0 nM 4.26
CHEMBL13823 Ki = 61800.0 nM 4.21
CHEMBL1160766 Ki = 72400.0 nM 4.14
CHEMBL404605 Ki = 90700.0 nM 4.04
CHEMBL1160769 Ki = 259000.0 nM -
CHEMBL1160768 Ki = 388000.0 nM -
CHEMBL20767 4-GUANIDINO-BENZOIC ACID Ki = 745000.0 nM -
CHEMBL297076 Ki = 676000.0 nM -
CHEMBL41853 Ki = 103000.0 nM -
CHEMBL1160764 Ki = 136000.0 nM -
CHEMBL1160765 Ki = 1450000.0 nM -
CHEMBL44236 Ki = 419000.0 nM -
CHEMBL1160767 Ki = 1330000.0 nM -