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Compound Detail

CHEMBL61138

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O=C(c1cc(N=C=S)cc2ccccc12)c1cn(CCN2CCOCC2)c2ccccc12

Basic Information

ChEMBL ID CHEMBL61138
Phase Preclinical
Structure Type MOL
InChI Key UITVVNWAQZMCRJ-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

441.6
MW (Da)
5.09
ALogP
6
HBA
0
HBD
46.8
PSA (Ų)
0.24
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H23N3O2S
MW 441.56
Aromatic Rings 4
Heavy Atoms 32
NP-Likeness -1.19

Activity Summary

IC50 1 meas. best 6.04

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 1
CHEMBL3571
IC50 6.04 6.04 920.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Cannabinoid receptor 1 IC50 = 920.0 nM 6.04 Binding affinity against brain cannabinoid receptor 1 using [3H]CP-55940 as radi... 8642555

Literature References

PubMed DOI Target Context # Activities
8642555 10.1021/jm950932r Cannabinoid receptor 1 1

Data from ChEMBL 36 via Core Engine