Assay Detail
Binding
CHEMBL657119
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Binding affinity against brain cannabinoid receptor 1 using [3H]CP-55940 as radioligand at 0.25 nM concentration
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(Aminoalkyl)indole isothiocyanates as potential electrophilic affinity ligands for the brain cannabinoid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.56 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13078 | — | — | 1 | 7.34 |
| CHEMBL61448 | — | — | 1 | 6.80 |
| CHEMBL436553 | — | — | 1 | 6.36 |
| CHEMBL301230 | — | — | 1 | 6.28 |
| CHEMBL61138 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13078 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL61448 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL436553 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL301230 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL61138 | — | IC50 | = | 920.0 | nM | 6.04 |