Compound Detail
CHEMBL61448
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Basic Information
| ChEMBL ID | CHEMBL61448 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LBSVQGQJTYJQKW-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
441.6
MW (Da)
5.09
ALogP
6
HBA
0
HBD
46.8
PSA (Ų)
0.24
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.96
IC50 1 meas. best 6.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 CHEMBL3571 | IC50 | 6.8 | 6.8 | 160.0 | 1 |
| Adenylate cyclase type 5 CHEMBL2880 | EC50 | 5.96 | 5.96 | 1100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cannabinoid receptor 1 | IC50 | = | 160.0 | nM | 6.8 | Binding affinity against brain cannabinoid receptor 1 using [3H]CP-55940 as radi... | 8642555 |
| Adenylate cyclase type 5 | EC50 | = | 1100.0 | nM | 5.96 | Compound was evaluated for inhibition of hormone stimulated Adenylate cyclase ac... | 8642555 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8642555 | 10.1021/jm950932r | Adenylate cyclase type 5 | 1 |
| 8642555 | 10.1021/jm950932r | Cannabinoid receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine