Compound Detail
CHEMBL62382
METHYLSELENOCYSTEINE Phase I
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Phase I
Basic Information
| ChEMBL ID | CHEMBL62382 |
| Name | METHYLSELENOCYSTEINE |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | XDSSPSLGNGIIHP-VKHMYHEASA-N |
3
Targets
9
Activities
1
Assay Types
0
PK Parameters
12
Publications
2
Known Names
3
Indications
Molecular Properties
182.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Adenoma Lymphoma Prostatic Neoplasms
Activity Summary
IC50 9 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mycolicibacterium smegmatis CHEMBL613088 | IC50 | 6.22 | 5.94 | 600.0 | 4 |
| Hs68 CHEMBL614578 | IC50 | 4.3 | 4.3 | 50000.0 | 1 |
| A-375 CHEMBL613859 | IC50 | 4.27 | 4.27 | 54000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mycolicibacterium smegmatis | IC50 | = | 600.0 | nM | 6.22 | Antimycobacterial activity against Mycobacterium smegmatis grown in nitrogen -li... | 19786608 |
| Mycolicibacterium smegmatis | IC50 | = | 600.0 | nM | 6.22 | Antimycobacterial activity against Mycobacterium smegmatis grown in nitrogen -li... | 19786608 |
| Mycolicibacterium smegmatis | IC50 | = | 2190.0 | nM | 5.66 | Antimycobacterial activity against Mycobacterium smegmatis grown in carbon-limit... | 19786608 |
| Mycolicibacterium smegmatis | IC50 | = | 2190.0 | nM | 5.66 | Antimycobacterial activity against Mycobacterium smegmatis grown in carbon-limit... | 19786608 |
| Hs68 | IC50 | = | 50000.0 | nM | 4.3 | Anticancer activity against human Hs68 cells assessed as cell growth inhibition ... | 34217061 |
| A-375 | IC50 | = | 54000.0 | nM | 4.27 | Anticancer activity against human A-375 cells assessed as cell growth inhibition... | 34217061 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19786608 | 10.1128/aac.00803-09 | Mycolicibacterium smegmatis | 12 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 8642562 | 10.1021/jm950750x | Kynurenine--oxoglutarate transaminase 1 | 1 |
| 12852761 | 10.1021/jm020496q | V79 | 1 |
| 12852761 | 10.1021/jm020496q | Unchecked | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 34217061 | 10.1016/j.ejmech.2021.113621 | A-375 | 1 |
| 34217061 | 10.1016/j.ejmech.2021.113621 | SW-620 | 1 |
| 34217061 | 10.1016/j.ejmech.2021.113621 | MCF7 | 1 |
| 34217061 | 10.1016/j.ejmech.2021.113621 | Hs68 | 1 |
Data from ChEMBL 36 via Core Engine