Compound Detail
CHEMBL64120
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CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1
Basic Information
| ChEMBL ID | CHEMBL64120 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KIUNCIUUHAZFFW-HSZRJFAPSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
485.6
MW (Da)
3.59
ALogP
6
HBA
0
HBD
79.4
PSA (Ų)
0.41
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL4124 | Ki | 6.92 | 6.92 | 120.2 | 1 |
| Histamine H1 receptor CHEMBL231 | Ki | 4.33 | 4.33 | 46773.5 | 1 |
| Histamine H2 receptor CHEMBL1941 | Ki | 4.3 | 4.3 | 50118.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 120.23 | nM | 6.92 | Binding affinity towards Histamine H3 receptor of rat cortical membranes. | 12113836 |
| Histamine H1 receptor | Ki | = | 46773.51 | nM | 4.33 | Binding affinity towards Histamine H1 receptor of human membranes. | 12113836 |
| Histamine H2 receptor | Ki | = | 50118.72 | nM | 4.3 | Binding affinity towards Histamine H2 receptor from human membranes | 12113836 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12113836 | 10.1016/s0960-894x(02)00310-4 | Histamine H3 receptor | 1 |
| 12113836 | 10.1016/s0960-894x(02)00310-4 | Histamine H1 receptor | 1 |
| 12113836 | 10.1016/s0960-894x(02)00310-4 | Histamine H2 receptor | 1 |
Data from ChEMBL 36 via Core Engine