Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL71595

HYDROGEN PEROXIDE
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug

Basic Information

ChEMBL ID CHEMBL71595
Name HYDROGEN PEROXIDE
Phase Approved
Structure Type MOL
InChI Key MHAJPDPJQMAIIY-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

A-101 Crystacide Eskata Hioxyl Hydrogen peroxide Hydrogen peroxide solution Hyrogen peroxide NSC-19892 Oxydol Peroxyl
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
10
Known Names
12
Indications
1
Mechanisms

Molecular Properties

34.0
MW (Da)
0.02
ALogP
2
HBA
2
HBD
40.5
PSA (Ų)
0.29
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2017
Availability Discontinued
Chirality Achiral

Routes of Administration

Topical

Flags

Natural Product

Extended Properties

Molecular Formula H2O2
MW 34.01
Aromatic Rings 0
Heavy Atoms 2
NP-Likeness 0.45

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Unknown - - - ✓

Indications

Gingivitis Infections Keratosis, Seborrheic Pharyngitis Tooth Diseases Warts Acne Vulgaris Breast Neoplasms Carcinoma, Basal Cell Severe Acute Respiratory Syndrome Wounds and Injuries Dental Caries

ATC Classification

A01AB02
hydrogen peroxide
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: STOMATOLOGICAL PREPARATIONS
D08AX01
hydrogen peroxide
Level 1: DERMATOLOGICALS
Level 2: ANTISEPTICS AND DISINFECTANTS
D11AX25
hydrogen peroxide
Level 1: DERMATOLOGICALS
Level 2: OTHER DERMATOLOGICAL PREPARATIONS
S02AA06
hydrogen peroxide
Level 1: SENSORY ORGANS
Level 2: OTOLOGICALS

Activity Summary

IC50 2 meas. best 4.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NCI-H1299
CHEMBL612255
 IC50 4.22 4.22 60000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
NCI-H1299 IC50 = 60000.0 nM 4.22 Cytotoxicity against human NCI-H1299 cells assessed as reduction in cell viabili... 26832785

Literature References

PubMed DOI Target Context # Activities
18316516 10.1128/aac.01666-07 Streptococcus mutans 18
31103404 10.1016/j.bmc.2019.04.032 ADMET 6
- 10.1016/j.cropro.2012.06.009 Podosphaera xanthii 6
29549842 10.1016/j.ejmech.2018.03.014 Leishmania amazonensis 6
22361137 10.1016/j.bmcl.2012.01.101 MCF7 4
26807546 10.1016/j.ejmech.2016.01.020 MCF7 4
28185719 10.1016/j.bmcl.2017.01.064 HeLa 3
29328656 10.1021/acs.jmedchem.7b01463 MIA PaCa-2 3
26750401 10.1021/acs.jmedchem.5b01503 HCT-116 3
- 10.1039/C2MD20272G Escherichia coli 3
30482548 10.1016/j.bmc.2018.10.045 PC-3 3
10091683 10.1016/s0960-894x(98)00744-6 Unchecked 2
27951486 10.1016/j.ejmech.2016.12.002 Trypanosoma brucei brucei 2
32809827 10.1021/acs.jmedchem.0c01016 Unchecked 2
26410073 10.1016/j.bmcl.2015.09.041 Leishmania major 2
- 10.1016/j.cropro.2012.06.009 Cucurbita maxima x Cucurbita moschata 2
- 10.1016/j.cropro.2012.06.009 Lagenaria siceraria 2
23214452 10.1021/jm3013097 U-87 MG 1
21846118 10.1021/jm200924c SK-N-MC 1
37956506 10.1016/j.bmc.2023.117530 MCF7 1

Data from ChEMBL 36 via Core Engine