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Compound Detail

CHEMBL76503

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O=C(CCNC1CCCCC1)NC(c1ccccc1)C1CCCCC1

Basic Information

ChEMBL ID CHEMBL76503
Phase Preclinical
Structure Type MOL
InChI Key BTKGKYBZHPQSBM-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

342.5
MW (Da)
4.74
ALogP
2
HBA
2
HBD
41.1
PSA (Ų)
0.75
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H34N2O
MW 342.53
Aromatic Rings 1
Heavy Atoms 25
NP-Likeness -0.74

Activity Summary

Kd 1 meas. best 6.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Kd 6.1 6.1 794.3 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Adrenergic receptor alpha-1 Kd = 794.33 nM 6.1 Alpha adrenergic receptor activity in rat aorta 2903931

Literature References

PubMed DOI Target Context # Activities
2903931 10.1021/jm00120a007 Adrenergic receptor alpha-1 1

Data from ChEMBL 36 via Core Engine