Compound Detail
CHEMBL77278
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL77278 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VSMAAVBAABUVMQ-UXBLZVDNSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
187.2
MW (Da)
1.99
ALogP
2
HBA
1
HBD
61.1
PSA (Ų)
0.57
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.3
Ki 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Monocarboxylate transporter 1 CHEMBL2073709 | IC50 | 6.3 | 6.3 | 500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Monocarboxylate transporter 1 | IC50 | = | 500.0 | nM | 6.3 | Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15... | 26005533 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2552117 | 10.1021/jm00130a020 | Epidermal growth factor receptor | 1 |
| 26005533 | 10.1021/acsmedchemlett.5b00049 | Monocarboxylate transporter 1 | 1 |
Data from ChEMBL 36 via Core Engine