Compound Detail
CHEMBL7981
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL7981 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | USNKYQXLHXAMIJ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
316.7
MW (Da)
4.13
ALogP
4
HBA
0
HBD
48.7
PSA (Ų)
0.73
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL3608 | IC50 | 4.33 | 4.33 | 46200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 46200.0 | nM | 4.33 | Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation | 10090785 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10090785 | 10.1021/jm980551o | Epidermal growth factor receptor | 3 |
| 10090785 | 10.1021/jm980551o | Platelet-derived growth factor receptor | 1 |
| 20829041 | 10.1016/j.bmcl.2010.08.089 | Unchecked | 1 |
| 22456307 | 10.1016/j.bmcl.2012.03.027 | HCT-116 | 1 |
Data from ChEMBL 36 via Core Engine