Assay Detail
Functional
CHEMBL711650
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Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.91 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7819 | — | — | 1 | 5.55 |
| CHEMBL7810 | — | — | 1 | 5.31 |
| CHEMBL7866 | — | — | 1 | 5.02 |
| CHEMBL266995 | — | — | 1 | 4.99 |
| CHEMBL440453 | — | — | 1 | 4.94 |
| CHEMBL7827 | — | — | 1 | 4.80 |
| CHEMBL7339 | — | — | 1 | 4.34 |
| CHEMBL7981 | — | — | 1 | 4.33 |
| CHEMBL7917 | TYRPHOSTIN AG-1478 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7819 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL7810 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL7866 | — | IC50 | = | 9550.0 | nM | 5.02 |
| CHEMBL266995 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL440453 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL7827 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL7339 | — | IC50 | = | 45200.0 | nM | 4.34 |
| CHEMBL7981 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL7917 | TYRPHOSTIN AG-1478 | IC50 | < | 100.0 | nM | - |