Compound Detail
CHEMBL7810
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Basic Information
| ChEMBL ID | CHEMBL7810 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YEELQJLZRMCLAG-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
405.9
MW (Da)
5.28
ALogP
4
HBA
1
HBD
51.5
PSA (Ų)
0.49
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 5.82 | 5.61 | 1500.0 | 2 |
| Epidermal growth factor receptor CHEMBL3608 | IC50 | 5.31 | 5.31 | 4930.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 1500.0 | nM | 5.82 | Inhibition of Epidermal growth factor receptor-dependent phosphorylation | 10090785 |
| Epidermal growth factor receptor | IC50 | = | 4000.0 | nM | 5.4 | Inhibition of Epidermal growth factor receptor | 10090785 |
| Epidermal growth factor receptor | IC50 | = | 4930.0 | nM | 5.31 | Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation | 10090785 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10090785 | 10.1021/jm980551o | Epidermal growth factor receptor | 3 |
| 10090785 | 10.1021/jm980551o | Platelet-derived growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine