Assay Detail
Binding
CHEMBL677887
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Inhibition of Epidermal growth factor receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.63 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7917 | TYRPHOSTIN AG-1478 | — | 1 | 8.22 |
| CHEMBL266995 | — | — | 1 | 8.10 |
| CHEMBL440453 | — | — | 1 | 7.42 |
| CHEMBL7866 | — | — | 1 | 7.19 |
| CHEMBL7827 | — | — | 1 | 7.02 |
| CHEMBL7819 | — | — | 1 | 6.77 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 6.00 |
| CHEMBL7339 | — | — | 1 | 5.90 |
| CHEMBL7810 | — | — | 1 | 5.40 |
| CHEMBL7699 | — | — | 1 | 4.23 |
| CHEMBL7801 | — | — | 1 | - |
| CHEMBL7981 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7917 | TYRPHOSTIN AG-1478 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL266995 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL440453 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL7866 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL7827 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL7819 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL44 | GENISTEIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL7339 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL7810 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL7699 | — | IC50 | = | 58800.0 | nM | 4.23 |
| CHEMBL7801 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL7981 | — | IC50 | = | 500000.0 | nM | - |