Compound Detail
CHEMBL7819
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL7819 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VUACFNCXZKTIEY-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
315.8
MW (Da)
3.57
ALogP
4
HBA
1
HBD
51.5
PSA (Ų)
0.79
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 6.77 | 6.145 | 170.0 | 2 |
| Epidermal growth factor receptor CHEMBL3608 | IC50 | 5.55 | 5.55 | 2830.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 170.0 | nM | 6.77 | Inhibition of Epidermal growth factor receptor | 10090785 |
| Epidermal growth factor receptor | IC50 | = | 2830.0 | nM | 5.55 | Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation | 10090785 |
| Epidermal growth factor receptor | IC50 | = | 3000.0 | nM | 5.52 | Inhibition of Epidermal growth factor receptor-dependent phosphorylation | 10090785 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10090785 | 10.1021/jm980551o | Epidermal growth factor receptor | 3 |
| 10090785 | 10.1021/jm980551o | Tyrosine-protein kinase ABL | 1 |
| 10090785 | 10.1021/jm980551o | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 10090785 | 10.1021/jm980551o | Protein kinase C alpha type | 1 |
| 10090785 | 10.1021/jm980551o | Platelet-derived growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine