Assay Detail
Binding
CHEMBL677889
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Inhibition of Epidermal growth factor receptor-dependent phosphorylation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.57 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7917 | TYRPHOSTIN AG-1478 | — | 1 | 6.92 |
| CHEMBL7810 | — | — | 1 | 5.82 |
| CHEMBL266995 | — | — | 1 | 5.70 |
| CHEMBL7819 | — | — | 1 | 5.52 |
| CHEMBL440453 | — | — | 1 | 5.22 |
| CHEMBL7827 | — | — | 1 | 4.92 |
| CHEMBL7866 | — | — | 1 | 4.90 |
| CHEMBL7981 | — | — | 1 | - |
| CHEMBL7339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7917 | TYRPHOSTIN AG-1478 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL7810 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL266995 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL7819 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL440453 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL7827 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL7866 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL7981 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL7339 | — | IC50 | > | 100000.0 | nM | - |