Compound Detail
CHEMBL266995
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL266995 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZDTZOBIXVNHHCR-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
287.7
MW (Da)
3.67
ALogP
4
HBA
3
HBD
73.6
PSA (Ų)
0.64
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 8.1 | 7.3 | 8.0 | 3 |
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 5.1 | 5.1 | 8000.0 | 1 |
| Epidermal growth factor receptor CHEMBL3608 | IC50 | 4.99 | 4.99 | 10200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 8.0 | nM | 8.1 | Inhibition of Epidermal growth factor receptor | 10090785 |
| Epidermal growth factor receptor | IC50 | = | 8.0 | nM | 8.1 | Inhibition of EGFR (unknown origin) | 38870715 |
| Epidermal growth factor receptor | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of Epidermal growth factor receptor-dependent phosphorylation | 10090785 |
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 8000.0 | nM | 5.1 | Inhibition of p60 c-Src tyrosine kinase | 10090785 |
| Epidermal growth factor receptor | IC50 | = | 10200.0 | nM | 4.99 | Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation | 10090785 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10090785 | 10.1021/jm980551o | Epidermal growth factor receptor | 3 |
| 10090785 | 10.1021/jm980551o | Tyrosine-protein kinase ABL | 1 |
| 10090785 | 10.1021/jm980551o | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 10090785 | 10.1021/jm980551o | Protein kinase C alpha type | 1 |
| 10090785 | 10.1021/jm980551o | Platelet-derived growth factor receptor | 1 |
| 38870715 | 10.1016/j.bmc.2024.117791 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine