Assay Detail
Binding
CHEMBL843059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p60 c-Src tyrosine kinase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.34 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7917 | TYRPHOSTIN AG-1478 | — | 1 | 5.57 |
| CHEMBL266995 | — | — | 1 | 5.10 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | - |
| CHEMBL7827 | — | — | 1 | - |
| CHEMBL440453 | — | — | 1 | - |
| CHEMBL7866 | — | — | 1 | - |
| CHEMBL7819 | — | — | 1 | - |
| CHEMBL7339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7917 | TYRPHOSTIN AG-1478 | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL266995 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL44 | GENISTEIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL7827 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL440453 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL7866 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL7819 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL7339 | — | IC50 | > | 100000.0 | nM | - |