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Compound Detail

CHEMBL80084

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COc1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1

Basic Information

ChEMBL ID CHEMBL80084
Phase Preclinical
Structure Type MOL
InChI Key GZJDRJSWKKELOI-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

397.5
MW (Da)
4.27
ALogP
4
HBA
2
HBD
62.8
PSA (Ų)
0.62
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H31N3O3
MW 397.52
Aromatic Rings 2
Heavy Atoms 29
NP-Likeness -1.70

Activity Summary

Kd 1 meas. best 6.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Histamine H2 receptor
CHEMBL2882
Kd 6.7 6.7 199.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1352351 10.1021/jm00091a012 Rattus norvegicus 3
1352351 10.1021/jm00091a012 Histamine H2 receptor 1

Data from ChEMBL 36 via Core Engine