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Compound Detail

CHEMBL851

PHENYL PROPIONIC ACID
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O=C(O)CCc1ccccc1

Basic Information

ChEMBL ID CHEMBL851
Name PHENYL PROPIONIC ACID
Phase Preclinical
Structure Type MOL
InChI Key XMIIGOLPHOKFCH-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
15
Publications
0
Known Names

Molecular Properties

150.2
MW (Da)
1.70
ALogP
1
HBA
1
HBD
37.3
PSA (Ų)
0.71
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C9H10O2
MW 150.18
Aromatic Rings 1
Heavy Atoms 11
NP-Likeness 0.14

Activity Summary

Kd 1 meas. best 2.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Kelch-like ECH-associated protein 1
CHEMBL2069156
Kd 2.5 2.5 3200000.0 1

Pharmacokinetic Data

Parameter Value Units Species
Fu 0.095 - Homo sapiens

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19615910 10.1016/j.bmc.2009.06.057 NON-PROTEIN TARGET 6
19615910 10.1016/j.bmc.2009.06.057 Tyrosinase 6
19615910 10.1016/j.bmc.2009.06.057 Unchecked 5
26967507 10.1021/acs.jmedchem.5b01963 No relevant target 4
33818106 10.1021/acs.jmedchem.0c02094 Kelch-like ECH-associated protein 1 3
26967507 10.1021/acs.jmedchem.5b01963 ADMET 2
29729985 10.1016/j.bmc.2018.04.043 Amyloid-beta precursor protein 2
33848153 10.1021/acs.jmedchem.1c00124 Unchecked 2
6094812 10.1021/jm00378a021 ADMET 1
19615910 10.1016/j.bmc.2009.06.057 B16 1
915902 10.1021/jm00221a013 Unchecked 1
26967507 10.1021/acs.jmedchem.5b01963 Molecular identity unknown 1
27156192 10.1016/j.bmc.2016.04.037 C-terminal-binding protein 2 1
29729985 10.1016/j.bmc.2018.04.043 No relevant target 1
32031798 10.1021/acs.jmedchem.9b01746 ATP-dependent Clp protease proteolytic subunit 1

Data from ChEMBL 36 via Core Engine