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Compound Detail

CHEMBL90507

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CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1

Basic Information

ChEMBL ID CHEMBL90507
Phase Preclinical
Structure Type MOL
InChI Key QWIBHYUDAZKJRB-DHIUTWEWSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

634.8
MW (Da)
4.14
ALogP
9
HBA
0
HBD
111.7
PSA (Ų)
0.42
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H42N2O8S2
MW 634.82
Aromatic Rings 2
Heavy Atoms 43
NP-Likeness -0.66

Activity Summary

Ki 1 meas. best 8.91

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 8.91 8.91 1.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11133078 10.1016/s0960-894x(00)00553-9 Muscarinic acetylcholine receptor M2 1
11133078 10.1016/s0960-894x(00)00553-9 Muscarinic acetylcholine receptors; M1 & M2 1
11133078 10.1016/s0960-894x(00)00553-9 Muscarinic acetylcholine receptors; M2 & M3 1

Data from ChEMBL 36 via Core Engine