Assay Detail
Binding
CHEMBL745479
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Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Benzylidene ketal derivatives as M2 muscarinic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 9.20 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76164 | — | — | 1 | 11.00 |
| CHEMBL328094 | — | — | 1 | 10.52 |
| CHEMBL90700 | — | — | 1 | 10.51 |
| CHEMBL308566 | — | — | 1 | 10.15 |
| CHEMBL94189 | — | — | 1 | 10.14 |
| CHEMBL94247 | — | — | 1 | 9.96 |
| CHEMBL91404 | — | — | 1 | 9.89 |
| CHEMBL328059 | — | — | 1 | 9.80 |
| CHEMBL433011 | — | — | 1 | 9.14 |
| CHEMBL93017 | — | — | 1 | 9.09 |
| CHEMBL90638 | — | — | 1 | 9.09 |
| CHEMBL91232 | — | — | 1 | 8.99 |
| CHEMBL90507 | — | — | 1 | 8.91 |
| CHEMBL328093 | — | — | 1 | 8.74 |
| CHEMBL92110 | — | — | 1 | 8.54 |
| CHEMBL92569 | — | — | 1 | 8.29 |
| CHEMBL328550 | — | — | 1 | 8.04 |
| CHEMBL328120 | — | — | 1 | 7.92 |
| CHEMBL90199 | — | — | 1 | 7.84 |
| CHEMBL328659 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76164 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL328094 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL90700 | — | Ki | = | 0.031 | nM | 10.51 |
| CHEMBL308566 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL94189 | — | Ki | = | 0.073 | nM | 10.14 |
| CHEMBL94247 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL91404 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL328059 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL433011 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL93017 | — | Ki | = | 0.823 | nM | 9.09 |
| CHEMBL90638 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL91232 | — | Ki | = | 1.02 | nM | 8.99 |
| CHEMBL90507 | — | Ki | = | 1.22 | nM | 8.91 |
| CHEMBL328093 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL92110 | — | Ki | = | 2.91 | nM | 8.54 |
| CHEMBL92569 | — | Ki | = | 5.07 | nM | 8.29 |
| CHEMBL328550 | — | Ki | = | 9.09 | nM | 8.04 |
| CHEMBL328120 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL90199 | — | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL328659 | — | Ki | = | 34.8 | nM | 7.46 |