Compound Detail
CHEMBL9249
(+)-EPITAXIFOLIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL9249 |
| Name | (+)-EPITAXIFOLIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CXQWRCVTCMQVQX-GJZGRUSLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
304.2
MW (Da)
1.19
ALogP
7
HBA
5
HBD
127.5
PSA (Ų)
0.50
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 5.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sclerostin CHEMBL3580487 | Kd | 5.58 | 5.58 | 2632.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sclerostin | Kd | = | 2632.0 | nM | 5.58 | Binding affinity to SOST (unknown origin) by SPR analysis | 38677061 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12643908 | 10.1016/s0960-894x(03)00088-x | Mus musculus | 4 |
| 20189399 | 10.1016/j.bmc.2010.01.046 | Unchecked | 4 |
| 38677061 | 10.1016/j.ejmech.2024.116414 | Sclerostin | 3 |
| 20189399 | 10.1016/j.bmc.2010.01.046 | ADMET | 1 |
| 23642481 | 10.1016/j.bmcl.2013.04.013 | 3T3-L1 | 1 |
| 23642481 | 10.1016/j.bmcl.2013.04.013 | Pancreatic triacylglycerol lipase | 1 |
Data from ChEMBL 36 via Core Engine