Assay Detail
Binding
CHEMBL5502132
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Binding affinity to SOST (unknown origin) by SPR analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the small molecular inhibitors against sclerostin loop3 as potential anti-osteoporosis agents by structural based virtual screening and molecular design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 6.45 | 7.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558704 | — | — | 1 | 7.71 |
| CHEMBL2021342 | — | — | 1 | 7.42 |
| CHEMBL455364 | — | — | 1 | 6.67 |
| CHEMBL5531992 | — | — | 1 | 6.63 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | 6.56 |
| CHEMBL5531959 | — | — | 1 | 6.40 |
| CHEMBL311498 | CIANIDANOL | 4.0 | 1 | 5.80 |
| CHEMBL9249 | (+)-EPITAXIFOLIN | — | 1 | 5.58 |
| CHEMBL5559172 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558704 | — | Kd | = | 19.6 | nM | 7.71 |
| CHEMBL2021342 | — | Kd | = | 37.66 | nM | 7.42 |
| CHEMBL455364 | — | Kd | = | 211.2 | nM | 6.67 |
| CHEMBL5531992 | — | Kd | = | 233.7 | nM | 6.63 |
| CHEMBL6466 | COUMARIN | Kd | = | 273.3 | nM | 6.56 |
| CHEMBL5531959 | — | Kd | = | 397.1 | nM | 6.40 |
| CHEMBL311498 | CIANIDANOL | Kd | = | 1579.0 | nM | 5.80 |
| CHEMBL9249 | (+)-EPITAXIFOLIN | Kd | = | 2632.0 | nM | 5.58 |
| CHEMBL5559172 | — | Kd | = | 4782.0 | nM | 5.32 |