Compound Detail
CHEMBL95760
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL95760 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SFQDQVWLPSONMD-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
356.5
MW (Da)
3.99
ALogP
6
HBA
1
HBD
71.5
PSA (Ų)
0.72
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 8.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; alpha-5/beta-3/gamma-2 CHEMBL2094122 | Ki | 8.59 | 8.59 | 2.6 | 1 |
| GABA-A receptor; alpha-3/beta-3/gamma-2 CHEMBL2094120 | Ki | 7.44 | 7.44 | 36.0 | 1 |
| GABA-A receptor; alpha-2/beta-3/gamma-2 CHEMBL2094130 | Ki | 7.24 | 7.24 | 57.0 | 1 |
| GABA-A receptor; alpha-1/beta-3/gamma-2 CHEMBL2094121 | Ki | 7.04 | 7.04 | 92.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; alpha-5/beta-3/gamma-2 | Ki | = | 2.6 | nM | 8.59 | Inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-5-beta-3-g... | 15125950 |
| GABA-A receptor; alpha-3/beta-3/gamma-2 | Ki | = | 36.0 | nM | 7.44 | Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-a... | 15125950 |
| GABA-A receptor; alpha-2/beta-3/gamma-2 | Ki | = | 57.0 | nM | 7.24 | Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-a... | 15125950 |
| GABA-A receptor; alpha-1/beta-3/gamma-2 | Ki | = | 92.0 | nM | 7.04 | Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-a... | 15125950 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15125950 | 10.1016/j.bmcl.2004.03.054 | GABA-A receptor; alpha-5/beta-3/gamma-2 | 2 |
| 15125950 | 10.1016/j.bmcl.2004.03.054 | GABA-A receptor; alpha-1/beta-3/gamma-2 | 1 |
| 15125950 | 10.1016/j.bmcl.2004.03.054 | GABA-A receptor; alpha-2/beta-3/gamma-2 | 1 |
| 15125950 | 10.1016/j.bmcl.2004.03.054 | GABA-A receptor; alpha-3/beta-3/gamma-2 | 1 |
| 15125950 | 10.1016/j.bmcl.2004.03.054 | Gamma-aminobutyric acid receptor subunit alpha-5 | 1 |
Data from ChEMBL 36 via Core Engine