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Target Snapshot

CHEMBL1075459 Target Snapshot

HCC1954 · CELL-LINE · Homo sapiens

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342Compounds
98Assays
23Approved Drugs
190.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HCC1954 as ChEMBL target CHEMBL1075459. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HCC1954
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075459
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HCC1954 still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHCC1954
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHCC1954
UniProt AccessionN/A

HCC1954

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HCC1954.

Review nameHCC1954
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

23
Approved
8
Phase III
11
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50170.0
EC5020.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3128043 9.48 IC50 0.33 Preclinical
CHEMBL94657 8.04 IC50 9.187 Clinical
CHEMBL553025 8.0 IC50 10.09 Approved
CHEMBL1738758 7.82 IC50 15.0 Clinical
CHEMBL3545252 7.66 IC50 21.92 Approved
CHEMBL96926 7.6 IC50 24.87 Preclinical
CHEMBL53463 7.35 IC50 45.0 Approved
CHEMBL4650215 7.22 EC50 60.0 Approved
CHEMBL4441293 7.0 IC50 100.0 Preclinical
CHEMBL159 6.92 IC50 121.72 Approved
Distribution

pChEMBL Value Distribution

24
5.0
15
5.5
11
6.0
5
6.5
3
7.0
3
7.5
2
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

INAVOLISIB
CHEMBL4650215
Approved 2024
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

98
Total Assays
139
Tested Compounds
1
Assay Types
Functional — 98 assays, 139 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 86 139 5.2
organism-based format 12 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine