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Evidence Snapshot

HCC1954

CHEMBL1075459 CELL-LINE Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:25:34Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL1075459
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HCC1954 as ChEMBL target CHEMBL1075459. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HCC1954
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075459
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why HCC1954 matters

As of 2026-09-13

HCC1954 is reviewed as HCC1954; the current evidence base includes 23 approved drugs, 342 compounds, and 98 assays, with lead potency reaching pChEMBL 9.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 23 approved drugs, 342 compounds, and 98 assays for this target. The dominant activity type is IC50. CHEMBL3128043 is the current potency anchor at pChEMBL 9.5.

Use CHEMBL3128043 as the tractability anchor when discussing potency (pChEMBL 9.5).

Activity source · ChEMBL 36 via Core Engine
23 approved pChEMBL 9.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why HCC1954 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

342
Total Compounds
98
Total Assays
23
Approved Drugs
IC50: 170.0, EC50: 20.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3128043
 9.5 IC50 —
No preferred name
CHEMBL94657
 8.0 IC50 Clinical
No preferred name
CHEMBL553025
 8.0 IC50 Approved
No preferred name
CHEMBL1738758
 7.8 IC50 Clinical
No preferred name
CHEMBL3545252
 7.7 IC50 Approved

Approved Drugs

Structure Compound First Approval
INAVOLISIB
CHEMBL4650215
 2024
DOCETAXEL
CHEMBL3545252
 1995
VINORELBINE
CHEMBL553025
 1994
DOXORUBICIN
CHEMBL53463
 1974
VINBLASTINE
CHEMBL159
 1965
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:25:34Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL1075459