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Target Snapshot

CHEMBL1293271 Target Snapshot

Serine/threonine-protein phosphatase · SINGLE PROTEIN · Candida dubliniensis (strain CD36 / CBS 7987 / NCPF 3949 / NRRLY-17841) (Yeast)

364Compounds
4Assays
0Approved Drugs
365.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt B9W6M3. Use UniProt B9W6M3 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt B9W6M3 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein phosphatase as ChEMBL target CHEMBL1293271, mapped to UniProt B9W6M3. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein phosphatase
SINGLE PROTEIN · Candida dubliniensis (strain CD36 / CBS 7987 / NCPF 3949 / NRRLY-17841) (Yeast)
As of 2026-09-14
ChEMBL target ID
CHEMBL1293271
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
B9W6M3
Serine/threonine-protein phosphatase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serine/threonine-protein phosphatase is the right protein anchor across sources, using UniProt B9W6M3 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSerine/threonine-protein phosphatase
UniProt AccessionB9W6M3
Component TypeProtein
Sequence Length607 aa

Serine/threonine-protein phosphatase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Serine/threonine-protein phosphatase, mapped to UniProt B9W6M3. Sequence length is 607 aa.

Mapped IDB9W6M3
Review nameSerine/threonine-protein phosphatase
OrganismCandida dubliniensis (strain CD36 / CBS 7987 / NCPF 3949 / NRRLY-17841) (Yeast)
Assay Mix

Activity Type Distribution

IC501.0
EC50364.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4798527 8.1 IC50 8.0 Preclinical
CHEMBL1420556 6.08 EC50 828.0 Preclinical
CHEMBL1546228 5.61 EC50 2468.0 Preclinical
CHEMBL3190873 5.59 EC50 2578.0 Preclinical
CHEMBL1386774 5.51 EC50 3074.0 Preclinical
CHEMBL1521297 5.42 EC50 3784.0 Preclinical
CHEMBL1328373 5.41 EC50 3921.0 Preclinical
CHEMBL1487639 5.41 EC50 3925.0 Preclinical
CHEMBL1484777 5.33 EC50 4663.0 Preclinical
CHEMBL1469579 5.26 EC50 5548.0 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
3
5.5
1
6.0
0
6.5
0
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

4
Total Assays
28
Tested Compounds
2
Assay Types
Functional — 3 assays, 28 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 28 4.9
organism-based format 1 0
Binding — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 1 8.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine