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Target Snapshot

CHEMBL1667668 Target Snapshot

Lysosomal alpha-glucosidase · SINGLE PROTEIN · Mus musculus

56Compounds
3Assays
2Approved Drugs
58.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P70699. Use UniProt P70699 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P70699 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Lysosomal alpha-glucosidase as ChEMBL target CHEMBL1667668, mapped to UniProt P70699. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Lysosomal alpha-glucosidase
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL1667668
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P70699
Lysosomal alpha-glucosidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Lysosomal alpha-glucosidase is the right protein anchor across sources, using UniProt P70699 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLysosomal alpha-glucosidase
UniProt AccessionP70699
Component TypeProtein
Sequence Length953 aa

Lysosomal alpha-glucosidase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Lysosomal alpha-glucosidase, mapped to UniProt P70699. Sequence length is 953 aa.

Mapped IDP70699
Review nameLysosomal alpha-glucosidase
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5040.0
EC5018.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1651629 5.4 IC50 4000.0 Preclinical
CHEMBL574645 5.4 IC50 4000.0 Preclinical
CHEMBL1651630 5.3 IC50 5000.0 Preclinical
CHEMBL4108560 5.18 EC50 6600.0 Preclinical
CHEMBL1651631 5.16 IC50 7000.0 Preclinical
CHEMBL2164024 5.16 EC50 7000.0 Preclinical
CHEMBL1651552 5.1 IC50 8000.0 Preclinical
CHEMBL1651628 5.1 IC50 8000.0 Preclinical
CHEMBL408500 5.1 IC50 8000.0 Preclinical
CHEMBL1029 5.05 IC50 9000.0 Approved
Distribution

pChEMBL Value Distribution

14
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

3
Total Assays
45
Tested Compounds
1
Assay Types
Binding — 3 assays, 45 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 30 4.6
single protein format 1 15 5.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine