Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL1854 Target Snapshot

Lutropin-choriogonadotropic hormone receptor · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
277Compounds
54Assays
0Approved Drugs
103.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Lutropin-choriogonadotropic hormone receptor shows approved-linked disease relevance led by infertility. 5 more disease programs remain visible in the same review block. 5 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P22888. Start with infertility, then reuse UniProt P22888 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with infertility, then reuse UniProt P22888 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 5 linked drugs
Open source guide
Disease program
infertility

Lutropin-choriogonadotropic hormone receptor shows approved-linked disease relevance led by infertility. 5 more disease programs remain visible in the same review block. 5 linked drugs remain visible in the same block.

Start review with infertility because it currently carries approved-linked support. Linked drugs include CHORIOGONADOTROPIN ALFA, GONADOTROPIN, CHORIONIC, LH (MENOTROPINS), LUTROPIN ALFA. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 5 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Lutropin-choriogonadotropic hormone receptor as ChEMBL target CHEMBL1854, mapped to UniProt P22888. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Lutropin-choriogonadotropic hormone receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1854
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P22888
Lutropin-choriogonadotropic hormone receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Lutropin-choriogonadotropic hormone receptor is the right protein anchor across sources, using UniProt P22888 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why infertility is currently framed as approved-linked support. It currently carries 5 linked drugs in the same disease frame.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLutropin-choriogonadotropic hormone receptor
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP22888
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLutropin-choriogonadotropic hormone receptor
UniProt AccessionP22888
Component TypeProtein
Sequence Length699 aa

Lutropin-choriogonadotropic hormone receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Lutropin-choriogonadotropic hormone receptor, mapped to UniProt P22888. Sequence length is 699 aa.

Mapped IDP22888
Review nameLutropin-choriogonadotropic hormone receptor
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Lutropin-choriogonadotropic hormone receptor shows approved-linked disease relevance led by infertility. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
infertility
5 linked drugs · 5 direct · 5 efficacy
Linked drugCHORIOGONADOTROPIN ALFA
Linked drugGONADOTROPIN, CHORIONIC
Linked drugLH (MENOTROPINS)
Linked drugLUTROPIN ALFA
Approved-linked Approved
hypogonadism
4 linked drugs · 4 direct · 4 efficacy
Linked drugCHORIOGONADOTROPIN ALFA
Linked drugGONADOTROPIN, CHORIONIC
Linked drugLUTROPIN ALFA
Linked drugMENOTROPINS
Approved-linked Approved
female infertility
3 linked drugs · 3 direct · 3 efficacy
Linked drugCHORIOGONADOTROPIN ALFA
Linked drugLUTROPIN ALFA
Linked drugMENOTROPINS
Approved-linked Approved
anovulation
2 linked drugs · 2 direct · 2 efficacy
Linked drugCHORIOGONADOTROPIN ALFA
Linked drugGONADOTROPIN, CHORIONIC
Approved-linked Approved
obesity
1 linked drug · 1 direct · 1 efficacy
Linked drugCHORIOGONADOTROPIN ALFA
Approved-linked Approved
positive regulation of ovulation
1 linked drug · 1 direct · 1 efficacy
Linked drugLUTROPIN ALFA
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with infertility because it currently carries approved-linked support. Linked drugs include CHORIOGONADOTROPIN ALFA, GONADOTROPIN, CHORIONIC, LH (MENOTROPINS), LUTROPIN ALFA. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseinfertility
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Assay Mix

Activity Type Distribution

IC5050.0
KI1.0
EC5052.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL246321 9.51 Ki 0.311 Preclinical
CHEMBL1651721 9.0 EC50 1.0 Preclinical
CHEMBL1651828 8.3 EC50 5.0 Preclinical
CHEMBL1651723 8.0 EC50 10.0 Preclinical
CHEMBL246321 7.7 EC50 20.0 Preclinical
CHEMBL1651829 7.62 EC50 24.0 Preclinical
CHEMBL1651823 7.57 EC50 27.0 Preclinical
CHEMBL1651831 7.41 EC50 39.0 Preclinical
CHEMBL1651824 7.37 EC50 43.0 Preclinical
CHEMBL1651826 7.26 EC50 55.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
20
5.5
11
6.0
18
6.5
12
7.0
3
7.5
2
8.0
0
8.5
1
9.0
1
9.5
pChEMBL
Assay Landscape

Assay Landscape

54
Total Assays
61
Tested Compounds
3
Assay Types
Binding — 35 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 26 2 6.0
single protein format 9 3 7.4
Functional — 18 assays, 61 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 12 58 6.5
assay format 6 3 5.7
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine