Compound Detail
CHEMBL1651721
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Basic Information
| ChEMBL ID | CHEMBL1651721 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OBTDWDIYUNCNGX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
482.6
MW (Da)
3.35
ALogP
8
HBA
4
HBD
122.0
PSA (Ų)
0.23
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lutropin-choriogonadotropic hormone receptor CHEMBL1854 | EC50 | 9.0 | 9.0 | 1.0 | 1 |
| Follicle-stimulating hormone receptor CHEMBL2024 | EC50 | 6.9 | 6.9 | 126.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lutropin-choriogonadotropic hormone receptor | EC50 | = | 1.0 | nM | 9.0 | Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stim... | 24900256 |
| Follicle-stimulating hormone receptor | EC50 | = | 126.0 | nM | 6.9 | Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as st... | 24900256 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900256 | 10.1021/ml100229v | Follicle-stimulating hormone receptor | 3 |
| 24900256 | 10.1021/ml100229v | Lutropin-choriogonadotropic hormone receptor | 2 |
Data from ChEMBL 36 via Core Engine